Answer:
Only when a microorganism has successfully established a site of infection in the host does disease occur, and little damage will be caused unless the agent is able to spread from the original site of infection or can secrete toxins that can spread to other parts of the body. Extracellular pathogens spread by direct extension of the focus of infection through the lymphatics or the bloodstream. Usually, spread by the bloodstream occurs only after the lymphatic system has been overwhelmed by the burden of infectious agent. Obligate intracellular pathogens must spread from cell to cell; they do so either by direct transmission from one cell to the next or by release into the extracellular fluid and reinfection of both adjacent and distant cells. Many common food poisoning organisms cause pathology without spreading into the tissues. They establish a site of infection on the epithelial surface in the lumen of the gut and cause no direct pathology themselves, but they secrete toxins that cause damage either in situ or after crossing the epithelial barrier and entering the circulation.
Most infectious agents show a significant degree of host specificity, causing disease only in one or a few related species. What determines host specificity for every agent is not known, but the requirement for attachment to a particular cell-surface molecule is one critical factor. As other interactions with host cells are also commonly needed to support replication, most pathogens have a limited host range. The molecular mechanisms of host specificity comprise an area of research known as molecular pathogenesis, which falls outside the scope of this book.
While most microorganisms are repelled by innate host defenses, an initial infection, once established, generally leads to perceptible disease followed by an effective host adaptive immune response. This is initiated in the local lymphoid tissue, in response to antigens presented by dendritic cells activated during the course of the innate immune response (Fig. 10.2, third and fourth panels). Antigen-specific effector T cells and antibody-secreting B cells are generated by clonal expansion and differentiation over the course of several days, during which time the induced responses of innate immunity continue to function. Eventually, antigen-specific T cells and then antibodies are released into the blood and recruited to the site of infection (Fig. 10.2, last panel). A cure involves the clearance of extracellular infectious particles by antibodies and the clearance of intracellular residues of infection through the actions of effector T cells.
Explanation:
if wrong correct me
Answer:
1. The one nearest the surface is the "zone of aeration", where gaps between soil are filled with both air and water. Below this layer is the "zone of saturation", where the gaps are filled with water.
2. Larger pores mean less friction between flowing water and the sides of the pores. Smaller pores mean more friction between flowing water and pore walls and more twists and turns for the water to navigate. A permeable material has a greater number of larger, well-connected pore spaces. An impermeable material has fewer, smaller pores that are poorly connected.
3. A cave is any cavity in the ground that is large enough that some portion of it will not receive direct sunlight.
A cavern is a specific type of cave, naturally formed in soluble rock with the ability to grow speleothems.
4. The size of the pores underground rock material has and if the pores are connected
5. Karst regions are formed when there is a chemical reaction between the groundwater and the bedrock. As rain, streams, and rivers flow over the earth's surface, the water mixes with the carbon dioxide that naturally exists in air, and the soil becomes acidic and corrodes the calcium carbonate rock. The carbonate solution seeps into fissures, fractures, crevices, and other depressions in the rock. Sinkholes develop and the fissures and crevices widen and lengthen. As the openings get larger, the amount of water that can enter increases.
Explanation:
What type of mutation has occurred in the following example?
Original DNA Sequence ATC GGC TAG GCA
Mutated DNA Sequence
ATC AGG CTA GGC
A) deletion mutation
I believe it is called meiosis
