Question

Calculate total ATP produced from a fatty acid of 32 carbons

Answer 1

Answer:

Total number of ATP molecules generated from a 32-carbon fatty acid = 206 ATP molecules

Explanation:

A 32 carbon fatty acid which undergoes complete beta-oxidation assuming that the fatty acid is fully saturated will pass through the beta-oxidation cycle 14 times to produce the following:

15 molecules of acetylCoA, 14 molecules of FADH₂, and 14 molecules of NADH.

Each of the 15 acetylCoA molecules can be further oxidized in the citric acid cycle to yield the following: 15 × 3 NADH; 15 × 1 FADH₂, and 15 ATP molecules from the substrate level phosphorylation occuring at the succinylCoA synthetase catalyzed-reaction.

Total FADH₂ produced = 15 + 14 = 29 molecules of FADH₂

Total NADH produced = 45 + 14 = 59 molecules of NADH

The FADH₂ and NADH will each donate a pair of electrons to the electron transfer flavoprotein and mitochondrial NADH dehydrogenase respectively of the electron transport chain, and about 1.5 and 2.5 molecules of ATP are generated respectively when these electrons are transfered to molecular oxygen.

Thus, number of molecules of ATP generated by 29 molecules of FADH₂ = 1.5 × 29 = 43.5 molecules of ATP.

Number of molecules of ATP generated by 59 molecules of NADH = 2.5 × 59 = 147.5

Sum of ATP generated from FADH₂ and NADH = 43.5 + 147.5 = 191 ATP molecules

Total number of ATP molecules generated = 191 + 15 = 206 ATP molecules

Total number of ATP molecules generated from a 32-carbon fatty acid = 206 ATP molecules