MAD (mitotic arrest deficient) are proteins related to spindle cell cycle checkpoint and it is important since they prevent the segregation of sister chromatids until all have bound to the spindle.
The cell cycle ensures the duplication of the genome and its distribution in daughter cells by passing through a coordinated and regulated sequence of events.
A series of checkpoints guarantee the orderly progression of the phases of cell division and the correct distribution of the duplicated genetic material in the daughter cells.
The checkpoints during mitosis are:
- At the end of stage G1 and before S.
- Before anaphase in mitosis.
- DNA damage checkpoints in G1, S or G2.
The checkpoint before anaphase in mitosis guarantees the separation of chromosomes, and operates by activating the Mad2 protein that prevents the degradation of segurin, until the conditions are appropriate.
That is, the Mad2 protein prevents the segregation of sister chromatids until they have all bound to the spindle.
Therefore, we can conclude that MAD (mitotic arrest deficient) are proteins related to spindle cell cycle checkpoint and it is important since they prevent the segregation of sister chromatids until all have bound to the spindle.
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Answer:
Cytokinesis divides the two cells into four daughter cells.
Explanation:
Meiosis is a type of cell division in which a single cell is divided into four daughter cells. These daughter cells are haploid i. e. half number of chromosomes. This type of cell division occurs only in sex cells of male and female organisms. There are two phases of meiosis. In meiosis 1, a single cell is divided into two daughter cells while in meiosis 2, these two daughter cells again divided into four daughter cells.
In the case presented above, of a patient diagnosed with
primary open-angle glaucoma (POAG), who is refusing therapy. The insistence of
the nurse that it is important for the patient to seek treatment is in a bid to
prevent blindness. This is because <span>without
medical intervention, glaucoma can lead to total permanent blindness
within just a few years.</span>
66% of new HIV infections occur in sub-saharan Africa.
