The advertisers treat teenagers as separate target audiences by having to advertise products that would attract the teenagers alone as the teenagers are not particularly attracted to things that they may target the adult audiences, that is why, they laid out products that would target the teenagers in means of separating the target audiences.
Answer:
1. P120 is degraded in the 26S proteasome
2. The 26S proteasome has a major role in protein degradation and is critical for protein homeostasis
3. Cell cycle and DNA replication are cellular processes regulated by the Ras and NFkB pathways
Explanation:
The proliferation-associated nucleolar protein (p120) is a protein known to be expressed during the interphase of the cell cycle, specifically in G1 and early S phase, where any problem with DNA replication trigger a checkpoint, i.e., a molecular cascade of signaling events that suspend DNA replication until the problem is resolved. In mammalian cells, the 26S proteasome is responsible for catalyzing protein degradation of about 80% (or even more) of their proteins. The 26S proteasome acts to degrade rapidly misfolded and regulatory proteins involved in the cell cycle, thereby having a major role in protein homeostasis and in the control of cellular processes. It is for that reason that inhibitors that block 26S proteasome function have shown to be useful as therapeutic agents in diseases associated with the failure of protein degradation mechanisms (e.g., multiple myeloma). The NF-κB are highly conserved transcription factors capable of regulating different cellular processes including, among others, cellular growth, inflammatory responses and apoptosis. Moreover, the MAPK/ERK pathway is able to transduce different signals received on the cell surface to the nucleus. The MAPK/ERK pathway is activated when a singling molecule binds to a cell receptor which triggers a signaling cascade that ends when a transcription factor induces the expression of target genes, ultimately producing a response in the cell (for example, the progression through the cell cycle).
Homointernal adalah hewan yang bersuhu tubuh panas dan tetap hewan-hewan ini adalah:
1)Ikan, terbagi
-ikan hiu
-ikan pari
2)Amfibi terbagi
-Kodok
3)Reptil
-buaya
-kura-kura
4)Burung terbagi
-ayam
-merak
-kasuari
Answer:a u have both ur parents genes Dd and Dd
Explanation:
The answer is apex and base. To simplify, the apex of the heart rests on the diaphragm and from its base, the great vessels emerge. In addition, blood vessels that are nearer to the pumping heart and must enlarge to endure pressure variations are named elastic arteries and foramen ovale permits blood to pass from the right to the left atrium, therefore avoiding to pass the fetal lungs.
