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TAS-120 helps the patients in becoming resistant to BGJ398 and FGFR2 mutations.
Anti-tumor activity has been observed in the patient with intrahepatic cholangiocarcinoma (ICC) that activates ATP-competitive fibroblast growth factor receptor gene fusions. This results in resistance and results in the development of mutation of FGFR2 kinase.
It was further reported in 4 patients with FGFR2 that they developed Debio 1347. It was due to the activation of TAS-120 that fight the FGFR2.TAS-120 is the inhibitor of FGFR and it is irreversible. In patients with FGFR2, an increase in the duration of FGFR inhibition, FGFR inhibitors can be sequenced in a planned manner along with the biopsy.
TAS-120 helps the patients in becoming resistant to BGJ398 and FGFR2 mutations.
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Answer:
Explanation:
:
D. when the stomata are open, CO2 can get in but water can get out
Explanation:
Stomata are openings in leaf epidermis that are small they permit the entry of carbon dioxide and also allow the exit of water vapour.
Opening and closing of stomata is regulated according to physiological needs of the leaf.
Carbondioxide that is diffuses into the leave is used for photosynthesis.
Plant regulates water loss from the stomata. during the hot and cold weather water is conserves to maintain a cool environment in plant this is done by closing of stomata.
