* More than 40 proteins and glycoproteins involved in the complement system are synthesized by the liver, macrophages, epithelial cells, they are present in the blood in plasmatic form, membrane, some have an enzymatic activity, regulator or membrane receptorThese are elements of the humoral innate immune response, they fight infections, purify immune complexes and apoptotic bodies.
<span>There are indeed three ways to activate the complement:</span>
Classical pathway: Activated by Immunoglobulins in immune complexes, aggregated Immunoglobulins, DNA, CRP, apoptotic bodies .......it involves nine fractions, starting with C1, then C4, C2, C3, to form a classical C5 convertase, then, activation of C5, C6, C7, C8, C9.
Alternative pathway: activated by polysaccharides (bacterial endotoxin), vascular wall poor in sialic acid, aggregated IgE ...C3b like is the first component in the alternate channel cascade, it will create an amplification loop, and form an alternative C5 convertase.
Lecithin pathway: Activated by mannose, fucose (carbohydrate of microorganisms)The first component is the complex MBL / MASP1 / MASP2: "mannose-binding protein": works according to the same principle as the complex C1 of the classical way (MASP2 cleaves the C4 and the rest of the cascade is equivalent to that of the classical way).
the three ways have the same outcome: A C5 convertase (formed by one of the pathways) cleaves C5 into C5a and C5b: C5b is deposited far from other fractions on the antigenic surface. The fixation of C5b in the cell is followed by that of C6, C7, C8, and C9 (9 molecules of C9): formation of the membrane attack complex (MAC) ==> Death of the cell by osmotic shock
The answer is cancer.
Cancer is an uncontrolled division of cells. The regulation of cell cycle is necessary for normal cell division. The first phase of the cell cycle is the G1 phase. If the G1 phase is affected, mistakes in this process lead to the uncontrolled division of cells called cancer.
Unlike freshwater fish, saltwater fish <span>often contain a lower concentration of salt than the water they live in.
so your answer is </span><span>A. often contain a lower concentration of salt than the water they live in.
hope that helps!!!!!</span>
Answer:
All of life can be divided into three domains, based on the type of cell of the organism: Bacteria: cells do not contain a nucleus. Archaea: cells do not contain a nucleus; they have a different cell wall from bacteria. Eukarya: cells do contain a nucleus.
Explanation:
