Question: Describe how a single amino acid substitution causes hemoglobin molecules to stick together. Use what you know about the structure of Hb and HbS, the properties of glutamic acid and valine, and how hydrophobicity causes molecules to behave in water.
Answer:
A Single amino acid must be polar to attract, just like water.
Explanation:
Sickle cell is an genetic illness and it is began by a alteration that arises in the beta sub units of the haemoglobin. Haemoglobin is a tetrameric protein made up of 2 alpha sub units and 2 beta sub units and it is the important part of the blood accountable for oxygen passage. Sickle cell is a illness that consequences from a replacement of a polar amino acid identified as glutamate with a non polar one valine at site six of the beta polypeptide component of haemoglobin. The replacement occurs as a consequence of a alteration in one of the bases in the beta-globin gene from adenine to thymine . As a outcome of this change, the beta polypeptide chains convert sticky in low oxygen circumstances since the valine sticks out of the chain and interrelates with neighboring non-polar amino acids.
The correct genotypes of the parents are <span>AaBb and Aabb
In a cross of these two genotypes presented in the image below, 5/8 of the offspring would be deaf.
The individuals marked with a red square would be deaf because of the recessive aa alleles and the rest of the progeny that is marked with green would be deaf because of the presence of the B dominant allele.</span>
The best way to characterize the role of Sherron Watkins in ,the downfall of Enron is she tried to alert Ken Law about the accounting scandal of Enron. Sherron Watkins is an American Former vice president of corporate Development at the Enron Corporation. Watkins testified about her role in the Enron fraud before committees of the U.S.House or Representatives and senate at the beginning of 2002.
Phenotypic variations in genetically identical organisms that grow in the same controlled environment may be due to mutation.
<h3>Mutation</h3>
This refers to a sudden change to the DNA sequence of living organisms.
When the DNA base sequence of organisms changes, the effect is shown in the morphology of organisms.
For organisms that are genetically identical but grow in different environments, phenotypic variations might exist as a result of environmentally acquired traits during the struggle to adapt to their environments.
In the same environment, however, genetically identical organisms are not expected to be phenotypically different, unless a mutation to the DNA of one has occurred.
More on mutation can be found here: brainly.com/question/17106056
The coenzyme required is pyridoxal phosphate. It is a vitamins B6 cofactor required for transamination reaction.
