When the body becomes stressed, the pituitary gland at the base of the brain releases ACTH (adrenocorticotropic hormone) which stimulates the adrenal glands to produce cortisol. The extra cortisol allows the body to cope with stressful situations, such as infection, trauma, surgery, or emotional problems.
The use of corticosteroids is strongly associated to the development of psychiatric/neurological side effects. These effects are due to the wide expression of GR in the brain, and their long-term modulation can lead to functional and anatomical alterations, which might be responsible for the observed side-effects.
The exact physical causes of colour blindness are still being researched but it is believed that colour blindness is usually caused by faulty cones but sometimes by a fault in the pathway from the cone to the brain.
I believe the answers are: - Printing press - Antiseptic ointments Printing press was first developed in 1400s (15th century) and used widely by churches to spread up their religious pamphlets. Antiseptic ointments first developed in 1860s in order to help with doctors' surgical process.
