1- C
2-A
3-C
4-D
5-A (not sure)
6-C
7-C
8-C
9-A
10-D
Answer:
<h2>A</h2>
Explanation:
1. Sickle cell anemia is an inherited condition, disorder (disease).
2. It is a recessive condition, in which red blood cell become mutated and converted to a sickle like shape, and there aren't enough healthy red blood cells to carry oxygen throughout the body.
3. This condition normally occur when, there is inheritance of two abnormal or mutated copies of the β-globin gene, one allele from each parent.
4. β-globin gene makes haemoglobin.
5. Sickle cell anemia results when glutamic acid being substituted by valine at position 6 ( in short E6V substitution).
6. So, it a single base-pair substitution in the gene encoding the beta subunit.
The amount of proteins which is forming the SDS-resistant aggregates is isolated and purified by using the PSIA-LC-MALDI proteomic approach9 specially made for brain tissues.
Explanation:
- It is known as a regulatory mechanism through which the variations in the incorporation of the exons into mRNA gives the production of more output which is to related protein, thus results in expanding possible genomic outputs.
- Amyloids are the β-sheets-rich protein fibrils which can cause neurodegenerative and other incurable human diseases trapping millions of humans across the world.
- RNA molecules which are colocalized with FXR1 in cortical neurons are insensitive to the treatment with RNase A.
- FXR1 also colocalizes in cortical neurons using the amyloid-specific dyes
- FXR1 is also known to make different forms of RNA molecules and affects their stability and translation efficiency17.
- To determine the binding energy of FXR1 with mRNA, the brain cryosections were hybridized with biotinylated poly-dT.
