Earth has seasons because our planet's axis of rotation is tilted at an angle of 23.5 degrees relative to our orbital plane the plane of Earth's orbit around the sun. The tilt in the axis of the Earth is called its obliquity.
De Mestral first conceptualized hook and loop after returning from a hunting trip with his dog in the Alps in 1941.After removing several of the burdock burrs (seeds) that kept sticking to his clothes and his dog's fur, he became curious as to how it worked. He examined them under a microscope, and noted hundreds of "hooks" that caught on anything with a loop, such as clothing, animal fur, or hair. He saw the possibility of binding two materials reversibly in a simple fashion,if he could figure out how to duplicate the hooks and loops.
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A transcriptional activator is a protein (transcription factor) that increases transcription of a gene or set of genes. Activators are considered to have positive control over gene expression, as they function to promote gene transcription and, in some cases, are required for the transcription of genes to occur. Most activators are DNA-binding proteins that bind to enhancers or promoter-proximal elements.The DNA site bound by the activator is referred to as an "activator-binding site". The part of the activator that makes protein–protein interactions with the general transcription machinery is referred to as an "activating region" or "activation domain".
Most activators function by binding sequence-specifically to a regulatory DNA site located near a promoter and making protein–protein interactions with the general transcription machinery (RNA polymerase and general transcription factors), thereby facilitating the binding of the general transcription machinery to the promoter.Other activators help promote gene transcription by triggering RNA polymerase to release from the promoter and proceed along the DNA. At times, RNA polymerase can pause shortly after leaving the promoter; activators also function to allow these “stalled” RNA polymerases to continue transcription.
The activity of activators can be regulated. Some activators have an allosteric site and can only function when a certain molecule binds to this site, essentially turning the activator on Post-translational modifications to activators can also regulate activity, increasing or decreasing activity depending on the type of modification and activator being modified.
In some cells, usually eukaryotes, multiple activators can bind to the binding-site; these activators tend to bind cooperatively and interact synergistically.
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In addition to overproduction, industrial monoculture predisposes farms to pest problems. To keep up with intensified production, farmers increased pesticide and fertilizer usage, crop density, and the number of crop cycles per season, but decreased crop diversity
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