1. In the heart, an action potential originates in the (E) sinoatrial node. The cardiac action potential is a term referring to the change in the membrane potential of heart cells causing the heart to contract. Cardiac action potentials are created by a group of specialized cells capable of generating automatic action potentials and are located in the right atrium of the heart. These cells are called sinoatrial node and sometimes are referred to as the natural pacemaker of the heart. This characterization originates from the fact that sinoatrial node continuously provides action potential and sets the rhythm of the heart function.
2. The sequence of travel by an action potential through the heart is (A) sinoatrial node, atrioventricular node, atrioventricular bundle, bundle branches, Purkinje fibers. As explained above, the cardiac action potential originates from the sinoatrial node. This action potential then travels through the atrioventricular node, which belongs to the electrical conduction system of the heart and is located between the atria and the ventricles. It is responsible for the electrical connection between the right atrium and the right ventricle. The action potential then travels to the atrioventricular bundle (or bundle of His), another part of the electrical conduction system of the heart. The atrioventricular bundle transmits the electrical impulses from the atrioventricular node to the bundle branches. The bundle branches then send the signal to the Purkinje fibers which send the electrical impulses to the ventricles, causing them to contract.
3. The correct answer is A. The generation of an action potential in the sinoatrial node causes the contraction of the atria. When the action potential passes from the sinoatrial node to the atrioventricular node, it slows down. This causes the transport of the electrical impulse from the atria to the ventricles to slow down. This delay enables the blood (from the contraction of the atria) to fill the ventricles before their contraction.
4. This statement is true. The interventricular septum is a structure which divides the two ventricles of the heart and it is composed of two branches, the left bundle and the right bundle branch. When the action potential reaches the interventricular septum, it then travels to the apex of the heart from where it travels upwards along the walls of the ventricles and the ventricular contraction begins.
5. This statement is true. The bundle branches gradually become Purkinje fibers located in the interior of the ventricular walls. Purkinje fibers are specialized cells and are responsible for conducting cardiac action potentials from the bundle branches to the ventricular walls. This signal transduction causes the muscle of the ventricular walls to contract.
Depolarization is a result of sodium channels opening as a result of chemical or pressure-based stimuli
Depolarization starts when a threshold stimulus applied on a neuron via Na+ mechanically operated channels that trigger action potential
Action potential is an efficient signaling process by which distantly located cells communicate to each other
Depolarization of membrane potential is due to influx of Na+ via voltage gated Na+ channels
Fast opening of voltage gated Na+ channel shifts membrane potential from -70mV to + 50mV at which voltage gated Na+ channels become inactive thus influx of Na+ abruptly stops
The important events of light reaction are (i) Excitation of chlorophyll molecule to emit a pair of electrons and use of their energy in the formation of ATP from ADP + Pi. This process is called photophosphorylation. Splitting of water molecule (a) (b) End products of light reaction are NADPH and ATP.
Plasminogen activator is a substance that activates plasminogen to plasmin. Plasminogen activator is a serine proteases which catalyze the activation of plasminogen. The damaged blood tissue releases tissue plasminogen. The plasmin is important to break fibrin polymers that is formed during clotting of the blood. Increased plasminogen levels cause blood clots to dissolve faster.