Answer:
A if not D choose whichever you think is more reasonable between A and D
Explanation:
Because Santa anna was untrustworthy and because that was a lot of ground to cover and he wasn't sure if it would be good for America
1. disease brought by colonists was a major factor. Kills millions
2. violent conflicts between the colonists and/or British forces against the natives
3. The westward expansion (there's a special name for it) Colonists kept colonizing deeper and deeper into the mainland until reaching the western sea coast. killing 10's of thousands on the way there
*millions died, possible around 10 mill
They believed it helped them in the afterlife that's why it was so important