Answer:
Please see below
Explanation:
The number of chromatids have been stated with the respective event when it occurs in that particular number in the following way:
<u>23 chromatids</u>
primary oocyte arrested prior to ovulation
spermatozoa
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<u>46 chromatids</u>
oogonium prior to S phase
<u>92 chromatids</u>
secondary polar body
The answer is A:
The SUGAR-PHOSPHATE CHAINS form the sides, and the BASE PAIRS form the rungs
<span>Lafora disease is the most severe teenage-onset progressive epilepsy, a unique form of glycogenosis with perikaryal accumulation of an abnormal form of glycogen, and a neurodegenerative disorder exhibiting an unusual generalized organellar disintegration. The disease is caused by mutations of the EPM2A gene, which encodes two isoforms of the laforin protein tyrosine phosphatase, having alternate carboxyl termini, one localized in the cytoplasm (endoplasmic reticulum) and the other in the nucleus. To date, all documented disease mutations, including the knockout mouse model deletion, have been in the segment of the protein common to both isoforms. It is therefore not known whether dysfunction of the cytoplasmic, nuclear, or both isoforms leads to the disease. In the present work, we identify six novel mutations, one of which, c.950insT (Q319fs), is the first mutation specific to the cytoplasmic laforin isoform, implicating this isoform in disease pathogenesis. To confirm this mutation's deleterious effect on laforin, we studied the resultant protein's subcellular localization and function and show a drastic reduction in its phosphatase activity, despite maintenance of its location at the endoplasmic reticulum.
I got my information from </span>https://www.ncbi.nlm.nih.gov/pubmed/14722920
Answer:a) decreased chromatin condensation
Explanation:
During eukaryotic cell division a chromatin becomes obvious and it is simply a mass of genetic material made up of DNA and proteins which condenses to form chromosomes.
The chromatin primarily function in the compression the DNA into a unit so compacted that will be so tiny and can fit within the nucleus.
Chromatin condensation is driven by condensins and interactions between histones.
Condensins however, are large protein complexes whose central role in cell division is chromosome organization and segregation.
Chemical manipulation as stated above is decreases the rate of chromatin condensation.
