Money, bank loans, food, paying their bills/taxes. Mainly money troubles.
Answer: Pioneers and settlers moved out west for different reasons. Some of them wanted to claim free land for ranching and farming from the government through the Homestead Act. Others came to California during the gold rush to strike it rich. Even others, such as the Mormons, moved west to avoid persecution.
When the body is given weakened/dead pathogenic material this helps build up an immune system towards the actual live infection. It prepares the body for the infection so that the person does not get sick.
Answer:
mid-to-late 3rd century to 543 CE
Explanation: