Yes, it is true that Methylation of EZH2 by PRMT1 regulates its stability and promotes breast cancer metastasis.
Enhancer of zeste homolog 2 (EZH2), a key histone methyltransferase and EMT inducer, is overexpressed in diverse carcinomas, including breast cancer.
However, the molecular mechanisms of EZH2 dysregulation in cancers are still largely unknown. Here, we discover that EZH2 is asymmetrically dimethylated at R342 (meR342-EZH2) by PRMT1.
meR342-EZH2 was found to inhibit the CDK1-mediated phosphorylation of EZH2 at T345 and T487, thereby attenuating EZH2 ubiquitylation mediated by the E3 ligase TRAF6.
We also demonstrate that meR342-EZH2 resulted in a decrease in EZH2 target gene expression, but an increase in breast cancer cell EMT, invasion and metastasis.
Moreover, we confirm the positive correlations among PRMT1, meR342-EZH2 and EZH2 expression in the breast cancer tissues. Finally, we report that high expression levels of meR342-EZH2 predict a poor clinical outcome in breast cancer patients.
Our findings may provide a novel diagnostic target and promising therapeutic target for breast cancer metastasis.
Learn more about breast cancer here : brainly.com/question/6747562
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answer: binary fission
explanation:
binary fission is when a single celled organism divides to asexually reproduce two new organisms
Answer:
diverse proteins embedded in a phospholipid bilayer
Explanation:
According to fluid mosaic model the cell membrane is made of bilayer of phospholipid. Many proteins are embedded in this bi layer. Carbohydrate and cholesterol are also found in different forms. Carbohydrate can either be attached to the embedded protein in which case it is called as glycoprotein or it can be connected to the lipid molecule in layer and called as glycolipid.
Proteins can be found in two forms too. They can either be embedded in the layer i.e. they can penetrate single or both layers. These proteins are called as integral proteins. They can also be present on one side of the membrane and not penetrate the lipid bilayer in which case they are called as peripheral proteins.
Answer:
Epidermal cells secrete the waxy hydrophobic substance cutin that polymerizes on the surface, forming a barrier to water evaporation. Epidermal cells are transparent because their plastids remain small and undifferentiated; hence light readily penetrates through to the photosynthetic tissues beneath the epidermis.
Explanation:
Answer:
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