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viva [34]
2 years ago
11

What are MAD (mitotic arrest deficient) proteins and when are they important in the cell cycle?

Biology
2 answers:
andrew-mc [135]2 years ago
7 0

Answer:

<h3>The mitotic arrest deficient protein MAD2B (MAD2L2) is a member of a MAD family of proteins and shows 48% similarity to MAD2 (MAD2L1) [1], [2]. Both MAD2 and MAD2B can bind to the anaphase promoting complex or cyclosome (APC/C), which is a downstream target of the mitotic spindle checkpoint.</h3>

Mademuasel [1]2 years ago
6 0

MAD (mitotic arrest deficient) are proteins related to spindle cell cycle checkpoint and it is important since they prevent the segregation of sister chromatids until all have bound to the spindle.

The cell cycle ensures the duplication of the genome and its distribution in daughter cells by passing through a coordinated and regulated sequence of events.

A series of checkpoints guarantee the orderly progression of the phases of cell division and the correct distribution of the duplicated genetic material in the daughter cells.

The checkpoints during mitosis are:

  • At the end of stage G1 and before S.

  • Before anaphase in mitosis.

  • DNA damage checkpoints in G1, S or G2.

The checkpoint before anaphase in mitosis guarantees the separation of chromosomes, and operates by activating the Mad2 protein that prevents the degradation of segurin, until the conditions are appropriate.

That is, the Mad2 protein prevents the segregation of sister chromatids until they have all bound to the spindle.

Therefore, we can conclude that MAD (mitotic arrest deficient) are proteins related to spindle cell cycle checkpoint and it is important since they prevent the segregation of sister chromatids until all have bound to the spindle.

Learn more here: brainly.com/question/9790187

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