Well notable has two meanings one being An important or famous person and the other being worthy of attention.
I don't think you are supposed to, but im not 100% sure
Answer:
B. harmed more patients with infections than they helped with surgery.
Explanation:
Before Joseph Lister was inspired by Pasteur's germ theory to perform sterile operations, doctors harmed more patients with infections than they helped with surgery.
This was because doctors didn't do enough to prevent the spread of bacteria through surgical equipment and in the end they ended up causing more problems for their patients than the help they gave.
Prior to Joseph Lister's sterilisation which was influenced by Pasteur's germ theory, surgeons were unhygienic and didn't wash their hands or change their clothing before surgery which made infections after surgery widespread.