The hypothesis by Coleman was that the product of the ob+ gene was the appetite suppressing hormone. Hence, the homozygous ob/ob mutant are in a position to synthesize that hormone, and its circulating level would be zero. He also hypothesized that the product of the db+ gene was the receptor for the appetite-suppressing hormone. Thus, the homozygous db/db mutant would be able to synthesize the hormone but would not be in a position to respond to it. It would eat excessively and produce large amounts of body fat, which in turn would produce large amounts of appetite-suppressing hormone . In the absence of a receptor, the db/db mutant's hormone level would remain abnormally high.
Coleman's hypothesis were confirmed when the precise functions of the ob+ and db+ genes were determined. The peptide hormone encoded by the ob+ gene was named Leptin.
Muscular exercise presents a dramatic test of the body's homeostatic control systems because it results in large amounts of heat production.
Homeostatic control systems- A body's physiological ability to maintain a steady internal environment in response to changes in the external environment is known as homeostasis.
Heat Production- The term "thermogenesis" refers to the process through which energy is lost by producing heat with specialization.
Energy- In biology, cells frequently store energy in macromolecules, especially lipids and carbohydrates (sugars). When chemical bonds are formed, such as during the redox reactions of cellular aerobic respiration, energy is released.
Redox Reactions- A reaction that happens when an oxidizing material and a reducing substance come into contact.
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Hypodermis is not a layer of the skin
Because Evolution, theory in biology postulating that the various types of plants, animals, and other living things on Earth have their origin in other preexisting types and that the distinguishable differences are due to modifications in successive generations
