When a DNA sequence alteration results in a stop codon rather than a codon that specifies an amino acid, it is known as a nonsense mutation. This is rarely seen in 10% of patients with genetic disease.
<h3>What is nonsense mutation?</h3>
A nonsense mutation in a DNA sequence causes a premature stop codon, also known as a nonsense codon, in the transcribed mRNA as well as a shortened, ineffective, and typically nonfunctional protein product.
Because stop codons, also known as nonsense codons, signal the completion of protein synthesis rather than encoding for an amino acid, they are the source of the term "nonsense mutation."
Examples of illnesses for which nonsense mutations have been implicated as contributing factors include: Cystic fibrosis (produced by the G542X mutation in the cystic fibrosis transmembrane conductance regulator); (CFTR) Beta-globin (thalassemia) Hurler disease.
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Traits are inherited trough the parents genes that are passed to the offspring trough both parents reproductive cells, that contain genes in their nucleus.
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A codon is a sequence of three nucleotides in DNA or RNA that codes for either a particular amino acid or tells the cellular machinery to start or stop using the code. It isn't located anywhere specific.
There are four bases found in DNA: adenine (A), cytosine (C), guanine (G), and thymine (T). Adenine forms a base pair with thymine, and cytosine forms a base pair with guanine. There is a one-to-one relationship in these base pairings (Chargaff’s rule), which means that if you know the percentage of any one of them within a given DNA sample, you can calculate the percentages of the other three. In this case, you're given the percentage of guanine, and you want to find out the percentage of adenine.
Since guanine base-pairs with cytosine and since there must be as much cytosine as there is guanine, 41% of the bases in this gene are cytosine as well. That means that adenine and thymine <em>together </em>make up the remaining 18% (100% − 41% G − 41% C) of the base pairs. If there must be an equivalence in the number of thymine and adenine bases per Chargaff's rule, then half of the remaining base pairs must comprise adenine and the other half comprise thymine. Half of 18% is 9%.
Thus, adenine makes up 9% of the bases in this gene.
