Nicotine causes the brain to release chemicals that make you feel pleasure but overtime you may need more and more nicotine to get the same effects can eventually lead to nicotine addiction which can lead to affects that cause decreased appetite heighten mood increase heart rate and blood pressure nausea diarrhea and increased alertness.
Your pulse can show you so much things! You can try to detect murmurs, or irregular heart beats, or you can see if your heart rate is in a healthy zone.