Answer:
1. P120 is degraded in the 26S proteasome
2. The 26S proteasome has a major role in protein degradation and is critical for protein homeostasis
3. Cell cycle and DNA replication are cellular processes regulated by the Ras and NFkB pathways
Explanation:
The proliferation-associated nucleolar protein (p120) is a protein known to be expressed during the interphase of the cell cycle, specifically in G1 and early S phase, where any problem with DNA replication trigger a checkpoint, i.e., a molecular cascade of signaling events that suspend DNA replication until the problem is resolved. In mammalian cells, the 26S proteasome is responsible for catalyzing protein degradation of about 80% (or even more) of their proteins. The 26S proteasome acts to degrade rapidly misfolded and regulatory proteins involved in the cell cycle, thereby having a major role in protein homeostasis and in the control of cellular processes. It is for that reason that inhibitors that block 26S proteasome function have shown to be useful as therapeutic agents in diseases associated with the failure of protein degradation mechanisms (e.g., multiple myeloma). The NF-κB are highly conserved transcription factors capable of regulating different cellular processes including, among others, cellular growth, inflammatory responses and apoptosis. Moreover, the MAPK/ERK pathway is able to transduce different signals received on the cell surface to the nucleus. The MAPK/ERK pathway is activated when a singling molecule binds to a cell receptor which triggers a signaling cascade that ends when a transcription factor induces the expression of target genes, ultimately producing a response in the cell (for example, the progression through the cell cycle).
Fish live completely in water, amphibians partly in water and land while reptiles live on land. Fish and reptiles have scales while amphibians have smooth skin. Fish breath through gills, amphibians through gills and lungs while reptiles through lungs. They are generally classified as vertebrates.
Compressed is the first blank and older is the second one
Frozen red blood cells that have been thawed, deglycerolized and reconstituted in an open system must be used within 24 hours.
Cryopreservation of Red blood cells (RBCs) can be done with a long time span of usability of 10 years. Glycerol safeguards RBCs during freezing and defrosting, yet it can cause hemolysis if it is not washed off or eliminated before transfusion. When a unit has been deglycerolized, the shelf life of RBCs in an open system is only 24 hours, bringing about sporadic utilization of Frozen RBCs from the outset of the procedure or in close system cases it is up to 14 days.
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I would go with lipids:) hope it helps
