Question

Typically, amides will hydrolyze under ________ conditions than esters. stronger milder more saline less vigorous more dilute.

Answer 1

Typically, amides will hydrolyze under milder conditions than esters.

So, second option is correct one.

In acidic medium, amide interact with the water molecules to give a carboxylic aid and salt of ammonia or amine salt whereas in a basic medium, amides interacts with water molecules to give carboxylic aid and salt of ammonia or amine salt. An amides will hydrolyze under milder conditions because amide is least reactive than ester. The electronegativiy of nitrogen is less than oxygen. So, nitrogen transfer more electron cloud than oxygen towards carbonyl carbon. So, carbonyl group of amide hydrolysis in milder condition than ester.

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