Question

On what carbon atoms does the 14CO2 used to synthesize malonyl-COA from acetyl-coa appear in palmitate?

Answer 1

14 carbon atoms do the 14CO2 used to synthesize malonyl-COA from acetyl-CoA appear in palmitate.

Acetyl-CoA is carboxylated into malonyl-CoA by the acetyl-CoA carboxylase enzyme. The joining of one acetyl-CoA molecule and one bicarbonate molecule requires energy from ATP.

Malonyl coenzyme A: acyl carrier protein transacylase is an enzyme that uses malonyl-CoA in the production of fatty acids (MCAT).

The highly controlled acetyl-CoA carboxylase (ACC) in the cytoplasm produces malonyl-CoA by carboxylation acetyl-CoA in biotin and ATP-dependent manner. Acetyl-CoA carboxylase is an enzyme that changes acetyl-CoA into malonyl-CoA. Malonyl-ACP is created when the malonyl group is added to an acyl carrier protein.

A condensation reaction between malonyl-ACP and acetyl-CoA results in acyl-ACP and the simultaneous release of CO2.

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