1answer.
Ask question
Login Signup
Ask question
All categories
  • English
  • Mathematics
  • Social Studies
  • Business
  • History
  • Health
  • Geography
  • Biology
  • Physics
  • Chemistry
  • Computers and Technology
  • Arts
  • World Languages
  • Spanish
  • French
  • German
  • Advanced Placement (AP)
  • SAT
  • Medicine
  • Law
  • Engineering
Tatiana [17]
2 years ago
12

3. Genetic ablation of tau in postnatal neurons rescues decreased adult hippocampal neurogenesis in a tauopathy model

Biology
1 answer:
almond37 [142]2 years ago
7 0

The required answer is Neurogenesis increases.

Neurogenesis:

  • Alzheimer's disease and other tauopathies have been linked to impaired adult hippocampal neurogenesis, which may be a factor in these diseases' learning and memory deficits. We examined adult neurogenesis in the hippocampal dentate gyrus of wild-type mice, Tg30 mice expressing an FTDP-17 mutant tau, and the same Tg30 mice deficient for mouse tau (Tg30/tauKO) in order to determine the impact of tau pathology, a frequent key-lesion in these diseases, on adult hippocampal neurogenesis. Unbiased stereological techniques were used to measure the density of the granular layer, the number of granule cells, and the number of neuronal precursors expressing the immature markers DCX or 3R-tau in the dentate gyrus (DG). It was also examined how neurogenic markers co-localized with human mutant tau.
  • The volume of the granular layer and the number of granule cells were significantly reduced in mutant tau Tg30 mice, but not in Tg30/tauKO animals. The number of cells expressing the proliferation marker Ki-67 and the number of neuronal precursors displaying the immaturity markers DCX or 3R-tau (the latter only expressed in wild-type and Tg30 mice) in the neurogenic sub granular zone of the DG were decreased in Tg30 but not in Tg30/tauKOmice.
  • In comparison to Tg30 mice, Tg30/tauKO mice had reduced levels of soluble human phosphate and phosphate-positive cell density in the DG. In Tg30 and Tg30/tauKO mice, the human mutant tau was expressed in adult granule cells but not in Sox2 positive neural stem cells, DCX positive neuronal progenitors, or immature newborn neurons. These findings show that adult hippocampus neurogenesis is impaired in tau FTDP-17 mutant mice due to a reduction in proliferation that affects the pool of neural progenitors.
  • These mutant tau animals did not express mutant tau in precursor cells, indicating that this neurogenic defect is not cell-autonomous. As this decreased adult neurogenesis was restored by reducing tau expression in Tg30/tauKO mice, it is interesting to note that expression of endogenous wild-type tau in mature granule cells was required to see this harmful effect of human mutant tau. These findings imply that human tauopathies also reduce adult hippocampal neurogenesis through the development of tau pathology in dentate gyrus granule cells by inhibiting proliferation of neural progenitors, and that reducing tau expression may be a way to reverse this impairment.

Learn more about neurogenesis here brainly.com/question/24500582

#SPJ4

You might be interested in
During which phase of mitosis do sister chromatids separate?
Dvinal [7]

Answer:

I think Anaphase II

Explanation:

Hope this help

6 0
3 years ago
Why does food nood to be digested?
ahrayia [7]

Answer:

To release the nutrients inside of it

Explanation:

8 0
3 years ago
Plz help me well mark brainliest if you are correct!
zimovet [89]
I think it’s a because that’s the easy question every
3 0
3 years ago
Read 2 more answers
A typical human cell expresses only about 5% of its genes at any time. The expression of a gene can be regulated during any step
ANTONII [103]

Answer:

Enzymes

Explanation:

The regulation of gene expression is the central dogma of life. It is a series or set of mechanisms in which genetic information in the DNA expresses in the form of RNA or protein. Cells give gene expression b different mechanisms as transcription, maturation of mRNA, and translation.

During these mechanisms, different gene-regulatory proteins are influenced. For example, a set of RNA polymerases that are proteins transcribe the DNA molecule during transcription. Transcription factors are also proteins that control the synthesis of proteins in the cell. These proteins are an enzyme that catalyse the gene regulation in the human cells.

3 0
3 years ago
Which of the following observations contributed to the cell theory?
saveliy_v [14]
I'm sorry but can you be a bit more specific on these following observations?
3 0
3 years ago
Read 2 more answers
Other questions:
  • Name the natural cycles that occur as a result of the earth moon sun system.
    9·1 answer
  • Most crimes involve some evidence relating to the human body; for that reason, what related science is frequently used in forens
    10·1 answer
  • How can fungi reproduce using spores?
    8·2 answers
  • Describe how a metamorphic rock might become a sedimentary rock over time.​
    14·1 answer
  • Will give Brainiest + 50 points for the correct answer
    12·1 answer
  • Clear selectic 5 po 14. A group of high school students wanted to use a decibel meter to test whether or not their classroom was
    11·1 answer
  • Which of these islands would likely have the most species diversity.
    5·1 answer
  • What are some of the reasons that organisms need nitrogen?
    10·2 answers
  • Which of the following is an example of a trade-off?
    11·1 answer
  • Causes columns of clouds to spin, and may form a funnel cloud. (2 words)
    11·1 answer
Add answer
Login
Not registered? Fast signup
Signup
Login Signup
Ask question!