Question

The citric acid cycle is the central reaction sequence in the cellular metabolism of humans and many other organisms. One of the key steps is catalyzed by the enzyme isocitrate dehydrogenase and the oxidizing agent NAD⁺. In yeast, the reaction is eleventh order:Rate = K[ enzyme ] [isocitrate]⁴[AMP]²[NAD⁺]m [Mg²⁺]²What is the order with respect to NAD⁺?

Answer 1

In yeast, the reaction is eleventh order:Rate = K[ enzyme ] [isocitrate]⁴[AMP]²[NAD⁺]m [Mg²⁺]². The order with respect to NAD⁺ is 2.

What is a citric acid cycle?

The citric acid cycle is also called the Krebs cycle. This is the main source of energy that happens in aerobic conditions.

The coefficient that is raised to the active concentration of the reactants is the order in the mass action law. It is determined experimentally and can be fractional, positive, negative, or zero.

Each reactant's order, which is increased to its power in the rate law, is added to determine the order of the entire reaction.

The overall rate = 11

Rate of overall reaction = 1 + 4 + 2 + m + 2 = 11

9 + m = 11

m = 2

Thus, the order with respect to NAD⁺ is 2.

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