Scientists have found that extracellular matrix component may induce specific gene expression in the embryonic tissues such as the liver and testes. For this to happen, there must be a direct communication between the extracellular matrix and the developing cells. The Integrins of transmembrane protein would most likely be involved in this kind of induction.
Integrins are the main principal receptors used by the cells of animal to bind to the matrix of extracellular. They are heterodimers and they function as transmembrane linkers between the actin cytoskeleton and the extracellular matrix. A cell can regulate the sticky activity of its integrins from within.
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The reason why humming birds need long beaks is to be able to get the nectar from the flowers, kind of like how we need straws to drink out of to go cups. Humming birds also have very long tongues that also help this process. Since humming birds beaks help them get the food they need, it makes them more successful in their environment.
Yes, it is true that Methylation of EZH2 by PRMT1 regulates its stability and promotes breast cancer metastasis.
Enhancer of zeste homolog 2 (EZH2), a key histone methyltransferase and EMT inducer, is overexpressed in diverse carcinomas, including breast cancer.
However, the molecular mechanisms of EZH2 dysregulation in cancers are still largely unknown. Here, we discover that EZH2 is asymmetrically dimethylated at R342 (meR342-EZH2) by PRMT1.
meR342-EZH2 was found to inhibit the CDK1-mediated phosphorylation of EZH2 at T345 and T487, thereby attenuating EZH2 ubiquitylation mediated by the E3 ligase TRAF6.
We also demonstrate that meR342-EZH2 resulted in a decrease in EZH2 target gene expression, but an increase in breast cancer cell EMT, invasion and metastasis.
Moreover, we confirm the positive correlations among PRMT1, meR342-EZH2 and EZH2 expression in the breast cancer tissues. Finally, we report that high expression levels of meR342-EZH2 predict a poor clinical outcome in breast cancer patients.
Our findings may provide a novel diagnostic target and promising therapeutic target for breast cancer metastasis.
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How would low tide most likely negatively affect the abundance of aquatic organisms?
:Low tide exposes aquatic organisms to air for extended periods of time.
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Answer:i found this on google and got it right
Explanation:
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Spindle fibers are used in cell division, and are made of microtubules. ... As the others have written, microtubules are a “track” that can move organelles around when “motor” proteins (that cleave ATP) pull those organelles. The spindle is what moves the chromosomes during mitosis and meiosis