Intracellular Potassium Shifts and Impaired Potassium Excretion leads to elevated plasma K levels.
What is Hyperkalemia?
Hyperkalemia, a potentially lethal condition, develops when serum potassium levels rise above 5.5 mmol/l.
Potassium is the most common intracellular cation and is crucial for many physiological functions, at a concentration of 100-150 mmol/l.The digestive system quickly and usually fully absorbs potassium.
Causes:
Increased Potassium intake: In adult patients with normal renal function, increased dietary potassium intake is a very rare cause of hyperkalemia, but it can be a significant factor in people with kidney disease.
Intracellular Potassium Shifts: Large amounts of intracellular potassium can be released into the extracellular area as a result of cellular damage. Excessive activity, rhabdomyolysis after a crush injury, or other hemolytic processes can all be to responsible for this.
Impaired Potassium Excretion: The most frequent cause of hyperkalemia is acute or chronic renal disease. Hyperkalemia may also result from tubular dysfunction brought on by aldosterone insufficiency or insensitivity.
Learn more about the Hyperkalemia with the help of the given link:
Gel electrophoresis is a process or a technique in which fragments of DNA are separated in terms of their sizes.
<em><u>The restriction enzyme is mixed with a DNA sample before the process. The restriction enzyme cut DNA at specific points into fragments which can then be separated based on their sizes on an agarose gel.</u></em>
When current is applied to the gel DNA move towards the positively charged electrode since DNA is negatively charged, with shorter fragments migrating faster through the gel in comparison with large fragments.
