Intracellular Potassium Shifts and Impaired Potassium Excretion leads to elevated plasma K levels.
What is Hyperkalemia?
Hyperkalemia, a potentially lethal condition, develops when serum potassium levels rise above 5.5 mmol/l.
Potassium is the most common intracellular cation and is crucial for many physiological functions, at a concentration of 100-150 mmol/l.The digestive system quickly and usually fully absorbs potassium.
Causes:
Increased Potassium intake: In adult patients with normal renal function, increased dietary potassium intake is a very rare cause of hyperkalemia, but it can be a significant factor in people with kidney disease.
Intracellular Potassium Shifts: Large amounts of intracellular potassium can be released into the extracellular area as a result of cellular damage. Excessive activity, rhabdomyolysis after a crush injury, or other hemolytic processes can all be to responsible for this.
Impaired Potassium Excretion: The most frequent cause of hyperkalemia is acute or chronic renal disease. Hyperkalemia may also result from tubular dysfunction brought on by aldosterone insufficiency or insensitivity.
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Complex trait or quantitative trait is a trait that doesn’t behave according to simple Mendelian inheritance laws. These traits show a continuous range of variation and are influenced by both environmental and genetic factors. It is often said that complex traits<span> are those that are influenced by more than one factor.</span>
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