Question

Octanol is slightly soluble in water, and water is very soluble in octanol. why is it important to presaturate octanol with water and water with octanol when measuring ow?

Answer 1

N-Octanol and water are chosen because the connection between a substance's hydrophilicity and lipophilicity is measured by $K_{OW}$ (n-Octanol/Water partition coefficient). When a chemical is more dissolves in fat-like solvents like n-octanol, the value is more significant than one,  when it's more dissolved in water, the value is lower.

What is the partition coefficient?

• The partition coefficient for the two-phase network comprising n-octanol and water is known as the $K_{OW}$ value. N-Octanol-Water Partition Ratio is another name for it.

• The connection between a substance's hydrophilicity (its ability to dissolve in water) and lipophilicity (its ability to dissolve in fat) is measured by $K_{OW}$. The value is bigger if a drug is more accessible in fat-like liquids like n-octanol and less if a compound seems more water-soluble.

• Owing to linkage or fragmentation, substances that are involved in the octanol-water combination as multiple synthetic entities are each given a unique $K_{OW}$ ratio.

So, N-Octanol is chosen because it has a carbon/oxygen ratio that is comparable to that of lipids and because it shows both hydrophobic and hydrophilic properties. N-octanol, therefore, resembles the makeup and characteristics of cells and other living things.

Learn more about octanol here:

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