Question

During transpeptidation, nucleophilic attack occurs between the α-amine group in the ____ site and the esterified carbon in the ____ site.

Answer 1

During transpeptidation, nucleophilic attack occurs between the α-amine group in the A site and the esterified carbon in the P site

What is transpeptidation ?

A chemical process in which an amino acid residue or peptide residue is transferred from one amino compound to another. This process occurs when a protease reversibly converts one peptide to another.

• a process where one or more amino acids are transferred from one peptide chain to another, as in the case of a transpeptidase activity, or where a peptide chain itself is produced, as in the case of the production of a bacterial cell wall.
• Peptidoglycan glyco-syltransferases create the glycan strands (PGTs). The most popular class of antibiotics' fatal targets are enzymes termed transpeptidases (TPs), which produce the peptide crosslinks: using beta-lactams

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