Yes, it is true that Mammalian target of rapamycin pathway mutations cause hemimegalencephaly and focal cortical dysplasia.
Focal malformations of cortical development, including focal cortical dysplasia (FCD) and hemimegalencephaly (HME), are important causes of intractable childhood epilepsy.
Using targeted and exome sequencing on DNA from resected brain samples and non-brain samples from 53 patients with FCD or HME, we identified pathogenic germline and mosaic mutations in multiple PI3K/AKT pathway genes in 9 patients, and a likely pathogenic variant in 1 additional patient.
Our data confirm the association of DEPDC5 with sporadic FCD but also implicate this gene for the first time in HME. Our findings suggest that modulation of the mammalian target of rapamycin pathway may hold promise for malformation-associated epilepsy.
Learn more about mutations here : brainly.com/question/17031191
#SPJ4
No I have not completed it but, I'd be happy to help you with any other questions you might have.
true,
Hope I helped! ( Smiles )
The image shows a red blood cell in different solution. The first image shows an RBC in a hypotonic solutions. The RBC swell and lyse because of the osmotic movement or referred to as hemolysis. The second image shows a normal RBC in an isotonic solution. There is no net change of water to the RBC. The third image shows a shriveled RBC in a hypertonic solution. The water leak out of the RBC briskly than it enters the cell. It is also called as crenated cell.
Answer - Option C - hypotonic solution
Explanation:
Photosynthesis is plants taking in water,carbon dioxide, and light to make sugar and oxygen. This is important because all living things need oxygen to survive. All producers make oxygen and sugar for the secondary consumers and then the carnivores eat animals that eat plants.
