The changes in drug distribution that influence to Sadie include decreased plasma proteins.
<h3>What is the relationship between plasma proteins and aging?</h3>
In aging, a decreased level of plasma proteins is indicative of a high rate of protein catabolism, associated with the use of these macromolecules stored in different tissues (e.g., bones, blood, etc).
In conclusion, the changes in drug distribution that influence to Sadie include decreased plasma proteins.
Learn more about plasma proteins and aging here:
brainly.com/question/14427200
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Pretty sure it’s studies because you read textbooks to learn more about the subject. So B.Studies
Continued use/ or addiction
They have been using it for a while and might start to get addicted if not already