Answer:
Explanation:
Pharmacophore (pharmacology) - The molecular framework responsible for a drug's biological activity. According to IUPAC — A pharmacophore is the ensemble of steric and electronic features that is necessary to ensure the optimal supramolecular interactions with a specific biological target structure and to trigger (or to block) its biological response.
Privileged structures are defined as molecular frameworks which are able of providing useful ligands for more than one type of receptor or enzyme target by judicious structural modifications.
1) The 1,4-dihydropyridine ring is present in many biologically important molecules that acts as an important scaffold for cardiovascular drug - a calcium antagonists and although it is technically not considered as a pharmacophore, it is considered as a privileged structure.
1,4-Dihydropyridine (DHP), belongs to the class of calcium antagonist that inhibits the influx of extracellular Ca+2 through the L-type voltage-dependent calcium channels.
A positional substitution in the 4-position is feasible in the heterocyclic ring which in turn culminates in various calcium channel antagonist activities and this heterocyclic ring is the common feature for various pharmacological activities such as anti-inflammatory activity, analgesic activity,
antihypertensive, antianginal, antitumor, antitubercular activity and antithrombotic .
Position on the heterocyclic ring binds to the L-type channel and also to N-type channel on membranes.
2.) The bioisosteres are not a suitable bioisostere for the traditional C-4 aryl or heteroaryl substitution which is necessary for calcium ion blockage thereby inhibiting it to function with the mechanism shared above.
The upper arm bone is the claveical
Answer:
They can reflect on getting a Job and doing good in life, they could kill a person without them even knowing it. The dangers of drugs Is that they can mess up your life or it could make you so messed up things to yourself. Drugs are bad because they could make life worse, and they could hurt people around you or people you love, drugs can lower your chances of achieving your goals because you could easily get fired or you can lose your mind enough just not to know what you're doing.
Explanation:
Answer:
DNA ⇄ RNA → PROTEINS.
Explanation:
Central dogma explains the flow of genetic information of the living organism. The DNA is converted to RNA by transcription and further into protein product by the process of translation. DNA can increase its number by replication process.
Retroviruses do not follow the central dogma and they have the ability to convert the RNA into the DNA molecule by the enzyme reverse transcriptase. Their central dogma is as follows:
DNA ⇄ RNA → PROTEINS.
Thus, the answer is DNA ⇄ RNA → PROTEINS.
