Pyruvate kinase catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP in the last step of glycolysis, for
ming pyruvate in the process. Vertebrates have several isozymes of pyruvate kinase, which can be allosterically inhibited by compounds including ATP and acetyl-CoA. What is an effect of cAMP-dependent protein kinase (PKA) inactivation of the liver isozyme but not the muscle isozyme? A. Phosphate from the dephosphorylation of the liver isozyme is used to generate ATP and provide energy for movement.
B. Glycolysis is inhibited in the muscle, but not liver, when blood sugar is low.
C. Under stress (fight-or-flight) conditions, muscle can use glycolysis to break down glucose.
D. Glycogen synthesis is promoted in the liver as an energy store.
The correct answer is under C under stress condition muscle can can use glycolysis to breakdown glucose.
Explanation:
Each and every metabolic process of our body remains under tight regulation by various compounds present inside our body.
For example the catabolic process glycolysis is regulated by ATP,citrate,acetyl CoA etc.
The cAMP dependent protein kinase inactivation of liver isozyme but not the muscle isozyme result in the occurrence of glycolysis in muscle during stress condition as gluconeogenesis cannot occur in muscle.
The drug has a concentration of 6 mg per 1 ml. Therefore, to know that number of ml containing 25 grams, we will simply do cross multiplication as follows: amount of drug = (25 x 1) / 6 = 4.1667 ml
Therefore, for the patient to receive 25 mg of methimazole, he/she should take 4.1667 ml of the drug solution.
