Answer and Explanation:
The mechanism of action of statins begins with the inhibition of a protein called HMG-CoA reductase, allowing its substrate to accumulate in the body and promote cholesterol reduction. At that moment, a transporter called OATP (Organic Anion Transporting Polypeptides) takes statins to the epatic tissue where they will be transformed and metabolized until they are eliminated through bile. This elimination is influenced by the P-glycoprotein, which is the main cause of the efflix presented by the bili. This process can get help from other molecules like some protease inhibitors, digoxin and cyclosporine.
Answer:
Smaller populations have a greater chance of having one allele expressed disproportionately.
Explanation:
Genetic drift corresponds to a drastic casual alteration of the natural order, reaching the genotypic concentration of one or several species, not preliminarily involving natural selection factors, but caused by sudden events. Such phenomenon is characterized by the occurrence of ecological catastrophes, for example: earthquakes, tsunamis, tornadoes, floods, burnings, avalanches and other processes, affecting a large population contingent. Thus limiting the genetic content of a particular group, restricted to the prevailing individuals.
In this situation, with low variability, differentiated individuals will experience a more significant selection pressure in relation to the ascending lineage, which minimized the achievements of selection due to the high number of living individuals. In this scenario, smaller populations will have a greater chance of having a disproportionately expressed allele as the number of members is reduced. We can also see this effect if by using a coin we imagine that heads and tails are two alleles in a population and each coin toss represents one member of that population.
<span>HWE is used with COIDS and non CODIS eligible DNA profiles to provide statistical caluclations for the rarity or uniqueness of profiles. Each STR kit test for a certian number of loci. Each lous has a set ladder of observed alleles. Each of these alleles has value for its observed frequency in a population. It is the rarity of each allele at each location that will give you the value for rarity of the profile as a whole. This rarity fo the profile is calucalted in CODIS under certian circumstances using to determine the eligibilty of a partial profile or a forensic mixture to determine its eligiblity for the different leves of the database.</span>
Answer:
Please re-format this question.
Explanation:
It is very hard to see what is going on.
Answer:
Nerve agent
Explanation:
A nerve agent is a chemical in which on exposure to humans affects the functioning of the nervous system. These chemicals are known to disrupt the process by which messages are transferred to the organs from the nerve. This disruption occurs by blocking the activity of acetylcholinesterase, which is responsible for the catabolism of a neurotransmitter, acetylcholine.
On exposure to a nerve agent, the muscles of the body become paralyzed and early symptoms is production of excess mucous such as in runny nose, pupil constriction and also difficulty in breathing.
These agents are sometimes used in chemical warfare. Examples include sarin, tabun etc.
