Question

Consider a cell that requires much more ribose5‑phosphate than NADPH. The cell needs ribose 5‑phosphate but has a relatively high concentration of NADPH and a low concentration of NADP+. These conditions may occur in rapidly dividing cells. What is the fate of glucose 6‑phosphate, glycolytic intermediates, and pentose phosphate pathway intermediates in this cell?

Answer 1

Answer:

The fate of glucose-6-phosphate,glycolytic intermediates and pentose phosphate pathways are described below

Explanation:

Fate of Glucose -6-phosphate

Glucose-6-phosphate undergo dephosphorylation to form glucose when there is an increase demand of glucose in the body.

Glucose-6-phosphate enters into pentose phosphate pathway to synthesize ribose-5-phosphate which is used during denovo pathway of purine nucleotide biosynthesis.

Fate of glycolytic intermediates

Glyceraldehyde-3-phosphate is an important intermediate of glycolysis.The glyceraldehyde-3-phosphate act as a precursor during lipogenesis that deals with the biosynthesis of triacylglycerol.

Fate of pentose phosphate pathway intermediates

Ribose-5-phosphate and NADPH are the important intermediates of pentone phosphate pathway.

 Ribose-5-phosphate act as a substrate molecule during the denovo biosynthesis pathway of purine nucleotides.

NADPH act as a reducing agent during fatty acid biosynthesis process.