If we're only counting 5 vowels (A, E, I, O, U) and 20 consonants (everything else, minus T), then there are
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ways of picking the vowels, and
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ways of picking the consonants.
We want the word to start with T, and we'll allow any arrangement of the other 4 letters, so that the total number of words is
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Keep in mind that this means words like TRIES and TIRES are treated as different.