The long term ill-ness one you would have had time to prepare for, but it doesn't make it any better. It just seems to not hurt as long. You'll be sad for a couple of days. The sudden unexpected one will tear you apart. You'll be shocked and for that you'll wonder, why them and how. You'll most likely be very sad for a long time.
Illness and disease. kidney failure, fatty liver, hepatitis, liver scarring, etc. Families can be broken up due to addiction, children abused, drunk driving....