When the immune system attacks itself.
I would argue that the quality of service given after waiting super LONG is inadequate in a healthcare industry.
Personally, I turned 17 a few months back and I had to get an allergy shot(no it didn't hurt XD) but my parents wasted so much time signing documentations probably like half an hour and the shot itself took like one minute and I was out of the office..
The Cleveland clinic says that allergies are the main cause for the high levels. But some other causes can include skin disorders, tumors and autoimmune disorders