Well in terms of bad.
They will not have enough people for the jobs they need. Not enough helpers for medical, fire, plumming, and all those jobs wise. It would also mean that the population for that area is dying off.
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Image result for How do archaeologists know that the Harappan civilization in the Indus River valley was advanced?
Various elements of the Indus Civilization are found in later cultures, suggesting the civilization did not disappear suddenly due to an invasion. Many scholars argue that changes in river patterns caused the large civilization to break up into smaller communities called late Harappan cultures.
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C. Keeping the lab neat and organized
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Most reasonable answer¯\_(ツ)_/¯