What is another name for a condensation reaction? what is another name for a condensation reaction? water formation catabolism d
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I have provided the full reaction scheme for the synthesis of 4-methyl-3-hexanone from the reaction of acetylene and bromoethane. Acetylene is initially reacted with NaNH₂ which is a strong base that deprotonates the C-H of the acetylene which creates a carbon nucleophile which will then attack the electrophilic carbon containing the bromo in bromoethane. This is a simple sn2 substitution. Essentially an ethyl group is added to each side of the triple bond in acetylene.
With the 3-hexyne in hand, the triple bond is reduced using Lindlar's catalyst which will hydrogenate only to the alkene and stop. The 3-hexene is then reacted with a peroxycarboxylic acid which is used to epoxidize the alkene, to give the epoxide.
The epoxide is reacted with the grignard reagent which treats the methyl as a strong nucleophile. The methyl adds to one carbon of the epoxide and opens the ring. The acid is added at the end to protonate the alcohol.
Finally, the alcohol is oxidized with chromic acid which will oxidize a secondary alcohol to the ketone. The final product is 4-methyl-3-hexanone.
With the 3-hexyne in hand, the triple bond is reduced using Lindlar's catalyst which will hydrogenate only to the alkene and stop. The 3-hexene is then reacted with a peroxycarboxylic acid which is used to epoxidize the alkene, to give the epoxide.
The epoxide is reacted with the grignard reagent which treats the methyl as a strong nucleophile. The methyl adds to one carbon of the epoxide and opens the ring. The acid is added at the end to protonate the alcohol.
Finally, the alcohol is oxidized with chromic acid which will oxidize a secondary alcohol to the ketone. The final product is 4-methyl-3-hexanone.