Epithelial cells best suited for resisting abrasion and preventing pathogen entry into deeper tissues are stratified squamous epithelial cells.
Stratified cells are layered cells, squamous cells are flat and epithelial cells are covering cells. Therefore, stratified squamous epithelial cells are flattened, layered covering cells arranged on a basement membrane.
Stratified squamous epithelial cells have very little to no intercellular spaces which prevent pathogen from passing through and entering into the deeper tissues. They are well suited for resisting abrasion because the uppermost layers are subsequently sloughed off and replaced before the basement membrane is exposed. These types of cells form the outermost layer of the skin.
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