Eukaryotic cells contain many membrane-bound organelles. An organelle is an organized and specialized structure within a living cell. The organelles include the nucleus, ribosomes, endoplasmic reticulum, Golgi apparatus, vacuoles, lysosomes, mitochondria, and, in plants, chloroplasts
Answer:
The answer is reciprocal chromosomal translocation
Explanation:
The Philadelphia chromosome (Ph) is the truncated chromosome 22 generated by the reciprocal translocation t(9;22)(q34;q11) and was first identified in 1960 in a patient with CML [3]. Translocation of the proto-oncogene tyrosine-protein kinase (ABL1) gene located on chromosome 9 to the breakpoint cluster region (BCR) gene located on chromosome 22 results in a BCR-ABL1 fusion gene on the Ph [4, 5]. Three BCR-ABL1 fusion gene hybrids encode BCR-ABL1 protein isoforms p210, p190, and p230, which have persistently enhanced tyrosine kinase (TK) activity. These aberrantly activated kinases disturb downstream signaling pathways, causing enhanced proliferation, differentiation arrest, and resistance to cell death [6, 7]. Tyrosine kinase inhibitors (TKIs) targeting the BCR-ABL1 protein are the most successful targeted therapy for Ph-positive leukemia.
In the small and large intestines
<span>Tight junctions, at the site of a tight junction, cells are held tightly against each other by many individual groups of tight junction proteins called claudins, each of which interacts with a partner group on the opposite cell membrane. For example, the tight junctions between the epithelial cells lining your bladder prevent urine from leaking out into the extracellular space.</span>
Answer:
The basic repeating unit of nucleic acids are known as nucleotides. A nucleotide consists of three distinct chemical groups, a 5-carbon sugar (ribose or deoxyribose), a nitrogen-rich base - (cytosine (C), guanine (G), adenine (A), thymine (T) in DNA or uracil (U) instead of T (in RNA), and phosphate.
