Sucrose, maltose, and lactose are common dietary disaccharides. Their monosaccharide components are substrates for the glycolyti
c pathway, but some must participate in additional reactions before they can act as substrates for a glycolytic enzyme. As a result, all do not enter glycolysis at the same step. In muscle cells, which enzyme would act as the rate-limiting step to regulate entry of products from all three dietary disaccharides into glycolysis?
PFK-1 is an important enzyme that plays a major role during glycolysis. It acts as a catalyst by converting fructose 6-phosphate and ATP into frustose 1,6-biphosphate and ADP. It regulates the process of glycolysis in the body. It controls the level of glucose and other disaccharides that goes down the glycolytic pathway. Low levels of pH and high ATP levels has an inhibitory effect on PFK-1.
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