Hi
It is true that the point of entry of a pathogen inside a body hold importance for the spread of pathogen. However, <em>organ and tissue specific manifestation is the real impact of a pathogen in any organism's body. Firstly we need to understand what is meant by Organ and tissue specific manifestation:</em>
It means that the specific organ or specific tissue is when affected by the entry of microbes or pathogens in the body, For example: The bacteria that cause tuberculosis enters the body through nose but manifests its action in lungs when multiplies there and affects the lungs' functionality and ultimately, depict the symptoms such as shortness and difficulty of breathing, this is basically organ specific manifestation.
Moreover, thee are some microbes that enter the body and damage certain tissues, for example HIV virus enters the body through sexual organs and travels to different tissues like nerve tissues, lymphatic system and damage them in a way that body's own immune system when counter reacts the microbes, it causes inflammation in the body and damage to overall tissues, This is called Tissue specific manifestation.
Hope it helps!
