The pH of the pond water and survival rate of animal species living in the pond has a direct relationship with each other. Animal species can survive at a specific level of pH"Optimum pH" at which these species can show their maximum activity.
If we decrease the pH the pond water will become more acidic and it will become challenging for species to survive in the acidic environment and if we increase the pH the water becomes more alkaline and again it affects the marine life. So, the pH of pond water should be in normal ranges.
Upregulation is where a increases the quantity of a cellular component like protein or RNA in response to an external stimulus.By controlling the number of its receptors, cells may increase and decrease their cell sensitivity.... Hormones can also trigger cells to control themselves by upregulation.( Estrogen is the primary sex hormone for females).