Answer:
eardrum,ossicles,cochlea nerve, cochlea
I hope this helps
Answer:
Exosomes as Therapeutic Target
Given the fact that elevated exosome levels are often correlated with greater severity of different types of cancer, reducing circulating exosomes to normal levels is one of therapeutic strategies to increase treatment efficacy. There are different approaches to modulate exosome production: 1) Inhibition of exosome formation: inhibit crucial proteins involved in exosome formation pathway; 2) Inhibition of exosome release: inhibit important regulators of exosome release process, increased intracellular Ca2+, change cellular microenvironmental pH; 3) Inhibition of exosome uptake: add proteinase for surface proteins on exosomes may serve as receptors for uptake pathways. In addition to control exosomes production, removal of exosomes from the entire circulatory system might be a novel strategy for cancer treatment.
Exosomes could also be used as cancer immunotherapy becasue tumor-derived exosomes carry antigens that is a great source of specific stimulus for the immune response against tumors. Both tumor-derived and dendritic cell-derived exosomes have showed capability to stimulate tumor antigen-specific responses in experimental animal models and human clinical trials.
Exosomes as Targeted Drug Delivery Vehicles
Exosomes became one of the most common methods applied in drug delivery system because of several advantages they have. Firstly, exosomes normally have a small size 40-100 nm, which is more homogenous compared to other microvesicles. This will lead them to evade rapid clearance by the mononuclear phagocyte and enhances passage through fenestrations in the vessel wall. Secondly, due to their endogenous origin, they are less toxic for and better tolerated by the immune system. It facilitates them to avoid causing side effects that normally occur with synthetic nanoparticles. Additionally, the specific ligand or protein expressed on the exosome surface increases efficiency of cargo into the cytosol of the target cell, and therefore fewer off-target effects. Exosomes are generally found most useful as a drug delivery medium in cancer therapy, anti-inflammation and gene interference therapy such as transferring of miRNA.
There are different kinds of cargos encapsulated by exosomes, especially like siRNA or miRNA. The delivery of RNA is attracting because they are rapid degradation in cell circulation and have the limitation in passing through the membrane and in cellular uptake. Chemotherapeutics loaded into exosomes is also used for cancer therapy such as doxorubicin. In principle, there are four key components to achieve correct functionality and efficacy during exosomes drug delivery:1) Choosing the donor cell type to produce drug-carrying exosomes; 2) Using correspond methods to encapsulate the exosomes cargo; 3) Enhancing the specificity of cargo delivery by targeting peptides on the surface of the exosomes; 4) Administrating exosomes to target the area of disease.
Explanation:
https://www.creative-biostructure.com/exosome-applications-652.htm
Answer/Explanation:
The DNA in all living organisms is made up of 4 bases, adenine, thymine, guanine, cytosine. The RNA replaces thymine with uracil, making 5 types of nucleotide. The number of nucleotide pairs in a genome can range from half a million up to 100,000 million - meaning there are an exponential number of combinations of these 4 bases.
Imagine an organism exists that has only 2 nucleotides (<u><em>this is over 200,000x smaller than even the smallest bacterial genome</em></u>). If we allow any nucleotide at each of the 2 positions, then we have 4x4 (4²) or 16 possible combinations of sequences. For a nucleotide length of 4, the total number of possible combinations are 4⁴ or 256.
Since we are dealing with many millions of nucleotides, there are essentially infinite combinations of nucleotides, giving rise to the variation that produces over 20 million organisms on the planet.
All can be used to make a new scientific law .
Answer:
Myelodysplastic (Ans. A)
Explanation:
Acute myeloblastic leukemia (AML): Is also called malignant blood cell cancer which can affect both adults & children. It is a fast-growing malignant disease where too many immature myeloblasts (WBS) are found in the RBC & bone marrow. Acute myeloblastic leukemia starts while chronic leukemia present from a long time & grow gradually. Symptoms of acute myeloblastic leukemia are:
High fever, a large no. of infections over a short period, pain in the joints, sweating a lot, etc.
Myelodysplastic syndrome: It is a group of disorder caused by blood cells (which is immature & don't work properly). Instead of developing properly the blood cells die in the bone marrow. After sometimes there are more immature cells than healthy ones, causing the problems infection caused by leukopenia, etc.
