The observation that abnormal cleavage of mannose residues from glycoproteins causes an autoimmune disease in mice supports the
role of this structure in the normal immune response. Identify the most likely subcellular site for the deficient or mutant protein in this scenario. A) Nucleolus.
B) Nucleus.
C) Agranular endoplasmic reticulum.
D) Granular endoplasmic reticulum.
E) Golgi apparatus.
F) Endosomes.
G) Peroxisomes.
H) Lysosomes.
I) Cytosol.
J) Cytoskeleton.
K) Glycocalyx.
The glycocalyx (also known as pericellular matrix) is a surface that surrounds the membrane cells, this coat is esecially composed by glycoproteins and is found both ineukaryotic and prokaryotic cells. The glycocalyx has many carbohydrates which have diverse cellular functions, including cell recognition, cell adhesion, and intercellular communication
The glycocalyx, also known as the pericellular matrix, is a subcellular site comprised of glycoproteins and glycolipids that surrounds the cell membranes of certain bacteria and most animal cells. It is more likely that the glycocalyx is the site that is affected in this scenario, since most glycoproteins have mannose residues and a disfunction in this area could lead to improper cells recognition, which is what happens during an autoimmune disease.
