On this case we have a <u>base</u> (methylamine) and an <u>acid</u> (2-methyl propanoic acid). When we have an acid and a base an <u>acid-base reaction </u>will take place, on this specific case we will produce an <u>ammonium carboxylate salt.</u>
Now the question is: <u>¿These compounds can react by a nucleophile acyl substitution reaction?</u> in other words <u>¿These compounds can produce an amide? </u>
Due to the nature of the compounds (base and acid), <u>the nucleophile</u> (methylamine) <u>doesn't have the ability to attack the carbon</u> of the carbonyl group due to his basicity. The methylamine will react with the acid-<u>producing a positive charge</u> on the nitrogen and with this charge, the methylamine <u>loses all his nucleophilicity.</u>
Explanation: In an endothermic reaction, it takes more energy to break the bonds of the reactants than is released when the bonds in the products are formed. In an endothermic reaction, the temperature goes down.