They are usually the most irritating line of defense and the body's reaction to a potential contaminant.
For example, when one touches poison ivy, the body will release histamines to react to the allergen. A blotchy red patch will appear on the skin (possibly several). An anti-histamine, like Benadryl, can help clam these symptoms.
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Inhaling particles from a wildfire can cause respiratory irritation, shortness of breath, asthma, and lead to long-term problems such as heart disease. If carbon monoxide is in the air, it can be fatal.
