A heart beat, breathing, and moving ;)
If the Na+ voltage-gated channels in a muscle cell open, the Na (sodium) ions rush inside the muscle cell and makes the cell more positive as Na ions carry positive charge on it. Due to the entry of positively charged ions inside the cell, the cell becomes less negative and more positive. This is called depolarization of cell.
<em>ATP stands for denosine tri phosphate ..
<u>formation:
</u>it is formed in the respiration ..also 36 molecules of ATP are formed during break down of 1 glucose molecule ..
<u>function:
</u>its function is to provide energy ,,
<u>how it provides energy:
</u>when one phosphate molecule separate ATP is converted into ADP and energy is released..
and when one phosphate is separated from ADP AMP is formed and energy is released ..</em>
In 15 patients with severe congenital ADAMTS-13 deficiency (plasma ADAMTS-13 activity 6%), the safety, tolerability, and pharmacokinetics of recombinant ADAMTS-13 were examined.
What is pharmacokinetics?
Pharmacokinetics (PK) is the study of how the body responds to drugs over the full exposure period (medications for the sake of this article). Pharmacodynamics, which closely evaluates the drug's impact on the body, is closely related to this yet clearly distinct from it. Absorption, distribution, metabolism, and excretion are the four primary variables this field often evaluates (ADME). Understanding these processes gives medical professionals the freedom to recommend and deliver drugs that will have the most benefit and the lowest danger, as well as to make adjustments as needed in light of the diverse physiology and lifestyles of their patients.
No significant side effects and no anti-ADAMTS-13 antibodies were found. BAX 930 was well tolerated. Adolescents and adults that received a single dose of BAX 930 at 5, 20, or 40 U/kg body weight showed approximately dose proportional maximum plasma concentration (Cmax [U/mL]) and area under the concentration-time curve (AUC [hU/mL]). Individual ADAMTS-13:Ag and activity levels increased in a dose-related manner and peaked within an hour. A dose-dependent persistence of von Willebrand factor (VWF) cleavage products caused by ADAMTS-13 and a smaller VWF multimeric size were seen with increasing BAX 930 dosages. It was shown in this investigation that BAX 930's pharmacokinetic parameters were similar to those predicted in earlier plasma infusion trials and that pharmacodynamic activity was present.
Complete Question
Recombinant ADAMTS-13: first-in-human pharmacokinetics and safety in congenital thrombotic thrombocytopenic purpura
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The responsibility of anything lies with the people. It is the government’s job to do what the people want it to do, and ultimately if it is not, it is the people’s responsibility to change that. Thinking there exists some separation between the will of the government and the will of the people is folly.
I know the typical argument. The government is not out for the interests of the people. This is often true….and yet we still pay them for this. Thus, we are ultimately and collectively complicit and approving of what they are doing, .
When enough people stand up and demand the government respond to more environmental protection issues, or anything else, they have to do it. It is not some big faceless AI entity. It's just a bunch of people, and if they don't listen to the other people that pay them, they lose their jobs.
